
The pupil (the circular black area in the middle of the coloured part of the eye) is usually the same size as the pupil on the other side, and the two pupils usually react together (for example to light). Bilateral miosis with little or no constriction to direct light, but with apparently normal, pupil constriction to near targets.Horner's syndrome that occurs very early in life can lead to iris heterochromia.
UNEQUAL PUPIL SIZE IN NEWBORN PATCH
Anhydrosis varies from the entire half face to a small patch on the forehead, depending on the location of the lesion.Anisocoria is more pronounced in the dark (particularly in the first 5 s of darkness).This sign is reportedly absent in 12% of Horner’s syndrome Classic triad of ipsilateral ptosis, pupillary miosis, and facial anhydrosis (absence of sweating), but rarely all signs present.The fellow pupil may become involved later Pupil may be oval-shaped or shows segmental constriction.Affected pupil larger than normal, with decreased response to light but preserved or enhanced near response.Degree of anisocoria remains relatively constant in light and dark conditions.Thought to result from a lesion in the midbrain that disables the pathway for the pupillary light reflex but does not affect the more ventral pathway mediating the near reaction.May occur after surgery (for example, to the neck) Potential causes in adults include neoplasia, demyelination and carotid artery disease.Caused by interruption of the oculosympathetic innervation at any point along the neural pathway from the hypothalamus to the orbit.Birth prevalence of 1 in 6250 for those with a congenital onset.When associated with absent or poor tendon reflexes known as Holmes-Adie syndrome.May also be seen in patients with generalised peripheral or autonomic neuropathies Sjögren’s disease and polyarteritis nodosa. Case reports of rare associations with connective tissue diseases e.g.
:max_bytes(150000):strip_icc()/illo-what-can-my-pupil-eye-size-tell-me-about-my-health-342186-59b1afd322fa3a0011f43d91.png)
Usually idiopathic but can occur following infection, orbital surgery or trauma affecting the ciliary ganglion.Prevalence 2 per 1,000 of the general population.

